منابع مشابه
Model Systems of Invertebrate Allorecognition
Nearly all colonial marine invertebrates are capable of allorecognition--the ability to distinguish between self and genetically distinct members of the same species. When two or more colonies grow into contact, they either reject each other and compete for the contested space or fuse and form a single, chimeric colony. The specificity of this response is conferred by genetic systems that restr...
متن کاملInvertebrate Allorecognition: The Origins of Histocompatibility
Alloimmune specificity and histocompatibility, driven by genetic polymorphism, are ancient determinants of self-/non-self-recognition. Recent molecular genetic evidence has revealed an allodeterminant in the cnidarian Hydractinia that consistently predicts histocompatibility reactions.
متن کاملAllorecognition Proteins in an Invertebrate Exhibit Homophilic Interactions
Sessile colonial invertebrates-animals such as sponges, corals, bryozoans, and ascidians-can distinguish between their own tissues and those of conspecifics upon contact [1]. This ability, called allorecognition, mediates spatial competition and can prevent stem cell parasitism by ensuring that colonies only fuse with self or close kin. In every taxon studied to date, allorecognition is control...
متن کاملEvolutionary aspects of allorecognition
Dear Editor, Although frequently neglected, allorecognition phenomena exhibit suites of effector mechanisms, altogether featuring one of the main biological characteristics of living organisms. A recent workshop organized by the Münster Graduate School of Evolution at the University of Münster, Germany, focused on the evolutionary aspects of allorecognition and the potential links to immune sys...
متن کاملWhat Is Direct Allorecognition?
Direct allorecognition is the process by which donor-derived major histocompatibility complex (MHC)-peptide complexes, typically presented by donor-derived 'passenger' dendritic cells, are recognised directly by recipient T cells. In this review, we discuss the two principle theories which have been proposed to explain why individuals possess a high-precursor frequency of T cells with direct al...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2019
ISSN: 0960-9822
DOI: 10.1016/j.cub.2019.03.039